Electronic detection of DNA mutation based on strand exchange reaction |
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| Authors: | Mariko Watanabe Satoshi Kumamoto Mitsunobu Nakamaura Kazushige Yamana |
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| Affiliation: | Department of Materials Science and Chemistry, University of Hyogo, 2167 Shosha, Himeji, Hyogo 671-2201, Japan |
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| Abstract: | A new approach to electronic detection of a single base mismatch is described. The assay involves the electrochemical measurements of DNA strand exchange reactions (SERs) between electrode-bound redox-modified DNA duplex and target DNA, where the sequence of redox-modified DNA is exchangeable to that of the target DNA. The presence of a single base mismatch can be determined from the slower SER rates compared with fully matched DNA. |
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