Synthesis and pharmacological activities of some sesquiterpene quinones and hydroquinones |
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| Authors: | Thorsten Laube Andreas Bernet Hans-Martin Dahse Ilse D. Jacobsen Karlheinz Seifert |
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| Affiliation: | 1. Lehrstuhl für Organische Chemie, NW II, Universität Bayreuth, D-95440 Bayreuth, Germany;2. Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e.V., Hans-Knöll-Institut, Beutenbergstr. 11 a, D-07745 Jena, Germany |
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| Abstract: | Synthesis of protected siphonodictyal C was achieved via drim-7-en-11-al. Some sesquiterpene quinones and hydroquinones were tested for their pharmacological activities in assays in search of antiproliferative, cytotoxic, antiphlogistic, antirheumatic and anti-inflammatory drugs. Wiedendiol B is a ten times stronger cyclooxygenase-2 inhibitor than the reference compound indomethacine. Cyclooxygenase-2 inhibitors are drugs with antiphlogistic and antirheumatic activity. |
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