Synthesis and dopaminergic activity of some E-3-(piperidin-1-yl)-1-(4-substituted phenyl)prop-2-en-1-one derivatives |
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| Authors: | Amirhossein Sakhteman Alireza Foroumadi Mohammad Sharifzadeh Masoud Amanlou Farhoud Rayatnia Abbas Shafiee |
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| Affiliation: | 1. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14174, Iran;2. Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran;3. Department of Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14174, Iran |
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| Abstract: | A convenient route for the synthesis of some 2-propen-1-one derivatives with E isomeric configuration is described. The activity of the synthesized compounds was evaluated through behavioral studies of apomorphine-induced licking in animal models. It was demonstrated that most of the synthesized compounds showed moderate activity in inhibition of lickings, among which 6a, was the most active compound at 30 mg/kg. |
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