Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations |
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| Authors: | Yamakawa Hidekuni Oyama Satoko Mitsuhashi Hiroaki Sasagawa Noboru Uchino Shigeo Kohsaka Shinichi Ishiura Shoichi |
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| Affiliation: | Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Tokyo, 3-8-1 Komaba, Meguro-ku 153-8902, Japan. |
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| Abstract: | Recently, neuroligins (NLs)3 and 4X have received much attention as autism-related genes. Here, we identified syntrophin-gamma2 (SNTG2) as a de novo binding partner of NL3. SNTG2 also bound to NL4X and NL4Y. Interestingly, the binding was influenced by autism-related mutations, implying that the impaired interaction between NLs and SNTG2 contributes to the etiology of autism. |
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| Keywords: | NL, neuroligin PDZ, PSD/Dlg/ZO-1 homology PSD, postsynaptic density DIV, days in vitro CNS, central nervous system |
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