Membrane‐mediated regulation of vascular identity |
| |
Authors: | Takuya Hashimoto Masayuki Tsuneki Trenton R Foster Jeans M Santana Hualong Bai Mo Wang Haidi Hu Jesse J Hanisch Alan Dardik |
| |
Institution: | 1. The Department of Surgery and the Vascular Biology and Therapeutics Program, Yale University, New Haven, Connecticut;2. Department of Surgery, VA Connecticut Healthcare Systems, West Haven, Connecticut;3. Department of Vascular Surgery, The University of Tokyo, Tokyo, Japan;4. Division of Cancer Biology, National Cancer Center Research Institute, Tokyo, Japan;5. Department of Vascular Surgery, The 1st Affiliated Hospital of Zhengzhou University, Henan, China |
| |
Abstract: | Vascular diseases span diverse pathology, but frequently arise from aberrant signaling attributed to specific membrane‐associated molecules, particularly the Eph‐ephrin family. Originally recognized as markers of embryonic vessel identity, Eph receptors and their membrane‐associated ligands, ephrins, are now known to have a range of vital functions in vascular physiology. Interactions of Ephs with ephrins at cell‐to‐cell interfaces promote a variety of cellular responses such as repulsion, adhesion, attraction, and migration, and frequently occur during organ development, including vessel formation. Elaborate coordination of Eph‐ and ephrin‐related signaling among different cell populations is required for proper formation of the embryonic vessel network. There is growing evidence supporting the idea that Eph and ephrin proteins also have postnatal interactions with a number of other membrane‐associated signal transduction pathways, coordinating translation of environmental signals into cells. This article provides an overview of membrane‐bound signaling mechanisms that define vascular identity in both the embryo and the adult, focusing on Eph‐ and ephrin‐related signaling. We also discuss the role and clinical significance of this signaling system in normal organ development, neoplasms, and vascular pathologies. Birth Defects Research (Part C) 108:65–84, 2016. © 2016 Wiley Periodicals, Inc. |
| |
Keywords: | vascular development embryo EphB4 ephrinB2 caveolae angiosarcoma |
|
|