Anticancer indole alkaloids of Ervatamia heyneana |
| |
| Authors: | Sarath P. Gunasekera Geoffrey Cordell Norman R. Farnsworth |
| |
| Affiliation: | Department of Pharmacognosy and Pharmacology, College of Pharmacy, University of Illinois at the Medical Center, Chicago, IL 60612, U.S.A. |
| |
| Abstract: | The wood and stem bark of Ervatamia heyneana (Apocynaceae) yielded 14 indole alkaloids and 3 triterpenoids. Six of these isolates, camptothecin (2), 9-methoxycamptothecin (3), coronaridine (1), pericalline (25), heyneatine (18) and 10-methoxyeglandine- N-oxide (4) displayed cytotoxic activity. Three of the indole alkaloids 18, 4 and 10-hydroxycoronaridine (8) are new members in the iboga series and their structures were determined by a combination of spectral interpretation and chemical correlation. |
| |
| Keywords: | Apocynaceae cytotoxic and antitumor activity chemical correlation indole alkaloids triterpenes. |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
