Structure of the alpha 1 subunit of horse Na,K-ATPase gene |
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| Authors: | I Kano F Nagai K Satoh K Ushiyama T Nakao K Kano |
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| Institution: | Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Japan. |
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| Abstract: | Genomic DNA for Na,K-ATPase alpha 1 subunit was obtained from libraries of horse kidney genomic DNA in Charon 4A and in EMBL3 bacteriophages by screening with the full sized cDNA probe of the alpha 1 subunit of rat Na,K-ATPase as probe. The gene spans 30 kb and consists of 23 exons and 22 intervening sequences. Intron-exon boundaries were analyzed. The protein-coding nucleotide sequence encodes 1016 amino acids with an Mr of 112,264. The putative amino acid sequence of horse alpha 1 is 96-97% homologous to those of other mammalian species. |
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