| PrPC与蛋白质X结合位点可及性的初步探讨 |
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| 引用本文： | 孙桂鸿,郭明雄,彭小雪,肖庚富,胡建民. PrPC与蛋白质X结合位点可及性的初步探讨[J]. 氨基酸和生物资源, 2003, 25(4): 28-32. DOI: 10.3969/j.issn.1006-8376.2003.04.008 |
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| 作者姓名： | 孙桂鸿 郭明雄 彭小雪 肖庚富 胡建民 |
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| 作者单位： | 1. 武汉大学生命科学学院,武汉,430072;武汉大学医学院,武汉,430071;2. 武汉大学生命科学学院,武汉,430072;3. 武汉大学医学院,武汉,430071 |
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| 基金项目： | 国家自然科学基金;30370054; |
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| 摘 要： | 根据PDB提供的PrPC的原子坐标,利用MSMS程序,对PrPC氨基酸残基溶剂可及表面积进行了计算和分析.结果表明:(1) PrPC氨基酸残基可及性具有总体一致性特点;(2) PrPC蛋白质序列中非保守残基与种间屏障有一定关系;(3) 在PrPC向PrP Sc转变过程中,由于蛋白质X的结合,PrPC可能会出现一定的构象变化,这种变化利于PrPC向PrPSc发生转变.
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| 关 键 词： | 朊病毒 分子伴侣 可及性 |
| 文章编号： | 1006-8376(2003)04-0028-05 |
| 修稿时间： | 2003-09-02 |
Preliminary Studies on the Accessibility of Amino Acid Residue Sites of PrPC to Bind Protein X |
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| SUN Gui-hong ,,GUO Ming-xiong,PENG Xiao-xue,XIAO Geng-fu ,HU Jian-min. Preliminary Studies on the Accessibility of Amino Acid Residue Sites of PrPC to Bind Protein X[J]. Amino Acids & Biotic Resources, 2003, 25(4): 28-32. DOI: 10.3969/j.issn.1006-8376.2003.04.008 |
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| Authors: | SUN Gui-hong GUO Ming-xiong PENG Xiao-xue XIAO Geng-fu HU Jian-min |
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| Affiliation: | SUN Gui-hong 1,2,GUO Ming-xiong1,PENG Xiao-xue1,XIAO Geng-fu 1*,HU Jian-min2 |
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| Abstract: | According to the atom's coordinate of prion protein amino acid residues from the PDB, we calculated and discussed the ASA of amino acid residues of prion protein using MSMS program. Results indicated: (1) the accessibility of PrPC amino acid residues had the characteristic of total consistency; (2) there was certain relation between the nonconservative residues of PrPC sequence and species barrier; (3) in the course of PrPC inverting into PrP Sc, because of the combination with protein X, PrPC may occur some conformational invertion , and it may benefit the transformation of PrPC to PrP Sc. |
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| Keywords: | prion molecular chaperone accessibility |
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