High-pressure enzyme kinetics. Lactate dehydrogenase in an optical cell that allows a reaction to be started under high pressure |
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Authors: | Drachev" target="_blank">V A Chernyak VYaDrachev N G Nikolaeva B V Chernyak |
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Institution: | Institute of Molecular Genetics, USSR Academy of Sciences, Kurchatov Square 46, 123182 Moscow, USSR |
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Abstract: | Interactions of adriamycin with ferritin-bound iron have been investigated. It is demonstrated (i) that adriamycin stimulates an iron-dependent lipid peroxidation in submitochondrial particles in the presence of ferritin, and (ii) that incubation of adriamycin with ferritin results in a slow transfer of iron to adriamycin with formation of an adriamycin-iron complex. The results are discussed in relation to the possible role for intracellular iron in adriamycin toxicity. |
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Keywords: | Lectin Crystal X-ray diffraction Three-dimensional structure Multichannel diffractometer |
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