Bile acid amidoalcohols: simple organogelators |
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Authors: | Valkonen Arto Lahtinen Manu Virtanen Elina Kaikkonen Suvi Kolehmainen Erkki |
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Institution: | Department of Chemistry, University of Jyv?skyl?, P.O. Box 35, FIN-40014 Jyv?skyl?, Finland. amvalkon@cc.jyu.fi |
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Abstract: | Simple bile acid amide synthesis of lithocholic and deoxycholic acids with 2-aminoethanol and 3-aminopropanol are reported. The structural properties of these amides were examined by NMR spectroscopic, ESI-TOF mass spectral, and X-ray crystallographic methods. The gelation properties of these amides in common organic solvents and in three different water solutions were also investigated using Tyndall effect, SEM, TEM, and optical microscopy. 2-Hydroxyethylamides were found to be effective gelators in chlorinated organic solvents and 3-hydroxypropylamides in aromatic solvents. Both derivatives thicken neutral and acidic water solutions. |
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