| 口蹄疫病毒和猪肠道病毒基因重组获得的c731重组株的进一步研究 |
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| 引用本文： | 熊光明.口蹄疫病毒和猪肠道病毒基因重组获得的c731重组株的进一步研究[J].病毒学报,1987(1). |
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| 作者姓名： | 熊光明 |
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| 作者单位： | 长春兽医大学 |
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| 摘 要： | 对不同属间小RNA病毒基因重组株c731,进行了病毒与细胞亲和力、毒蛋白的PAGE,病毒的乳鼠毒力和免疫原性试验,进一步证实,c731是口蹄疫病毒和猪肠道病毒通过基因重组产生的新病毒株。
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| 关 键 词： | 病毒重组 病毒蛋白Western印迹 毒力 免疫原性 口蹄疫病毒 猪肠道病毒 |
FURTHER CHARACTERIZATION OF VIRUS c731 OBTAINED FROM GENETIC RECOMBINATION BETWEENFOOT AND MOUTH DISEASE VIRUS AND PORCINE ENTEROVIRUS |
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| Xiong Guangming.FURTHER CHARACTERIZATION OF VIRUS c731 OBTAINED FROM GENETIC RECOMBINATION BETWEENFOOT AND MOUTH DISEASE VIRUS AND PORCINE ENTEROVIRUS[J].Chinese Journal of Virology,1987(1). |
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| Authors: | Xiong Guangming |
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| Abstract: | In a previous paper, we reported 10 genetic recombinants of FMDV and EV isolated by dual infection of IBRS-2 cell culture with these two viruses. A cloned strain, c731, was obtained, which possessed some properties of both FMDV and EV.In this paper we report the results of further characterization of c73l strain.Vpl of c731 capsid was found to be a hybrid protein reacting with both EMDV and EV antisera. The virulence of c731 for mice was mardekly lower than that of the original FMDV strain. Inoculation with c731 resulted in antibody production and protection against challenge with virulent FMDV virus. |
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| Keywords: | Virus recomin(?)tion Western blot Virulence Immunogenicity Foot and mouth disease virus Porcine enterovirus |
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