| PACAP对神经系统疾病保护作用的研究进展 |
| |
| 作者姓名： | Mao SS Zhang YM |
| |
| 作者单位： | 徐州医学院麻醉生理学教研室,江苏省麻醉学重点实验室,徐州,221004 |
| |
| 基金项目： | 江苏省教育厅自然科学基金,江苏省脑病重点实验室开放课题,徐州医学院院长基金(09KJZ17;09KJZ33)资助课题 |
| |
| 摘 要： | 垂体腺苷酸环化酶激活肽(pituitary adenylate cyclase-activating polypeptide,PACAP)存在于中枢神经系统内,作为神经递质、神经调质、神经营养因子及生长因子通过多种途径发挥神经保护作用.对脑缺血-再灌注损伤、创伤性脑损伤、精神分裂症、焦虑症、帕金森病、阿尔茨海默病等重大疾病具有重要的神经保护作用.本文就PACAP对神经系统疾病的保护作用及其机制的研究进行综述.
|
| 关 键 词： | 脑缺血-再灌注损伤 创伤性脑损伤 精神分裂症 |
Research advance of the protective role of PACAP in the nervous system diseases |
| |
| Mao SS,Zhang YM.Research advance of the protective role of PACAP in the nervous system diseases[J].Progress in Physiological Sciences,2011,42(4):276-280. |
| |
| Authors: | Mao Shan-shan Zhang Yong-mei |
| |
| Institution: | MAO Shan-Shan,ZHANG Yong-Mei(Department of Anesthesia Physiology,Xuzhou Medical College Jiangsu Key Laboratory of Oresthesiology,Xuzhou 221004,China) |
| |
| Abstract: | In the central nervous system,pituitary adenylate cyclase-activating polypeptide(PACAP) exerts different actions as neurotransmitter,neuromodulator,neurotrophic and neuroprotective factors via multiple signaling pathways.PACAP plays an important protective role in the nervous system diseases,such as focal cerebral ischemia,traumatic brain injury(TBI),schizophrenia,anxiety disorders Parkinson's disease and Alzheimer's disease.Now,we reviewed the research advances about the protective role of PACAP in the ner... |
| |
| Keywords: | PACAP |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ |
|
