| 肾素-血管紧张素系统与糖尿病心肌病关系的研究进展 |
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| 引用本文： | Zhang YC,Mou YL,Xie YY. 肾素-血管紧张素系统与糖尿病心肌病关系的研究进展[J]. 生理科学进展, 2011, 42(4): 269-275 |
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| 作者姓名： | Zhang YC Mou YL Xie YY |
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| 作者单位： | 山东省医学科学院药物研究所山东省罕少见病重点实验室,济南,250062 |
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| 基金项目： | 国家自然科学基金,山东省自然科学基金(Y2007C156)资助课题 |
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| 摘 要： | 糖尿病时,肾素-血管紧张素系统(renin-angiotensin system,RAS)被激活,升高的血管紧张素Ⅱ(Ang Ⅱ)通过细胞表面的AT1受体,刺激心肌成纤维细胞增生及胶原代谢改变,引起心脏结构重塑,导致心肌间质及血管周围纤维化,胶原含量增多和排列紊乱,造成心室肌僵硬而影响舒张功能,出现糖尿病心肌病(diabetic cardiomyopathy,DCM)的临床症状.本文从RAS的主要成分Ang Ⅱ、Ang-(1-7)、Ac-SDKP和血管紧张素受体(ATR)与内皮素、活性氧、转化生长因子-β1、核因子-κB、信号转导系统以及细胞凋亡之间的相互作用,阐述RAS在糖尿病心肌病发生发展中所起的重要作用.
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| 关 键 词： | 肾素-血管紧张素系统 糖尿病心肌病 转化生长因子-β1 核因子-κB 心肌纤维化 |
Research progress in relations between renin angiotensin system and diabetic cardiomyopathy |
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| Zhang Yi-chi,Mou Yan-ling,Xie Yan-ying. Research progress in relations between renin angiotensin system and diabetic cardiomyopathy[J]. Progress in Physiological Sciences, 2011, 42(4): 269-275 |
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| Authors: | Zhang Yi-chi Mou Yan-ling Xie Yan-ying |
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| Affiliation: | ZHANG Yi-Chi,MOU Yan-Ling,XIE Yan-Ying(Institute of Materia Medica,Shandong Academy of Medical Sciences,Key Laboratory for Rare Disease of Shandong Province,Jinan 250062,China) |
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| Abstract: | Renin-angiotensin system (RAS) is activated in diabetes. The rise of angiotension II (Ang II) stimulates the cardiac fibroblast proliferation and the alteration of collagen metabolism through AT1 receptor on cell surface, causing the myocardium interstitial and perivascular fibrosis, and the ventricular myocardium rigidity and diastolic function disturbance, leading to the clinical symptoms of diabetic cardiomyopathy (DCM). The main members of RAS including Ang II, Ang-(1-7), Ac-SDKP and ATR play the important role in the development of DCM. This article reviewed the interactions between RAS and endothelin (ET), reactive oxygen species (ROS), transforming growth factor-beta 1 (TGF-beta 1), nuclear factor-kappa b (NF-kappaB), signal transduction system and apoptosis in DCM. |
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