Influence of yohimbine on release of anterior pituitary hormones |
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| Authors: | M R Goldberg R V Jackson J Krakau D P Island D Robertson |
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| Affiliation: | 1. Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA;2. Department of Public Health Sciences, Medical University of South Carolina, 135 Cannon Street, Charleston, SC 29425, USA;3. Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA;4. Ralph H Johnson VAMC, 109 Bee Street, Charleston, SC 29401, USA;1. Department of Physiology, Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran;2. Neurophysiology Research Center, Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran;3. Immunogenetic Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran;4. Department of Physiology and pharmacology,School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran;1. Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, United States;2. Department of Pharmacology and Physiology, Drexel University, Philadelphia, PA 19102, United States |
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| Abstract: | We used a double-blind crossover design to study the effects of alpha 2 adrenoreceptor blockade with yohimbine on levels of anterior pituitary hormones. A dose of yohimbine was used which raised plasma norepinephrine from 379 +/- 74 (S.E.) to 730 +/- 143 pg/ml and mean arterial pressure from 83 +/- 4 to 92 +/- 5 torr (p less than 0.025). This dose (125 micrograms/kg, then 1 microgram/kg/min) also altered mood when compared to saline infusion. In spite of these changes, when prolactin, cortisol, ACTH, beta-endorphin, TSH and growth hormone were measured after 45 minutes of yohimbine infusion, no changes from baseline were noted. These data suggest that in normal man, at rest, alpha 2 adrenoreceptors in the hypothalamus, adenohypophysis or other brain areas do not tonically modulate release of these hormones into the blood. |
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