Effect of oligomeric derivatives of prostaglandin B1 on oxidative phosphorylation and their Ca2+ ionophoretic activity |
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| Authors: | T M Devlin R Krupinski-Olsen S Uribe G E Nelson |
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| Affiliation: | 1. Department of Biological Chemistry Hahnemann University School of Medicine, Philadelphia, PA 19102 USA;2. Department of Chemistry St. Joseph''s University, Philadelphia, PA 19131 USA;1. The National Research Centre For The Working Environment, Lersø Parkallé 105, DK 2100, København Ø, Denmark;2. National Food Institute, Technical University of Denmark, Kemitorvet, DK 2800 Kgs. Lyngby, Denmark;1. Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA;2. Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA;3. Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA;1. Laboratory of Trace Element Analysis, Biochemistry and Molecular Biology, Hôpital Edouard Herriot, Lyon, France;2. Nutrition Risk Assessment Unit, French Agency for Food, Environmental and Occupational Health & Safety (ANSES), 14 rue Pierre et Marie Curie, 94701 Maisons-Alfort Cedex, France;3. AgroParisTech, UMR914 Nutrition Physiology and Ingestive Behavior, 16 rue Claude Bernard, F-75005 Paris, France;1. The National Research Centre for the Working Environment, Lersø Parkalle 105, DK-2100, Denmark;2. Research group for risk-benefit, National Food Institute, Technical University of Denmark, Kemitorvet, DK 2800 Kgs., Lyngby, Denmark |
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| Abstract: | Dimers, trimers and tetramers of 15-dehydro-PGB1 and of 16,16'-dimethyl-15-dehydro-PGB1 have been synthesized and their effect on mitochondrial function evaluated. The trimers and tetramers, and to a lesser extent the dimers, of both series, protected isolated mitochondria from the loss of phosphorylating capacity during in vitro incubation. The monomers were inactive. The trimers and tetramers inhibited between 40 and 50% the F1F0-ATPase of submitochondrial particles. All of the oligomers, but not the monomers, had Ca2+ ionophoretic activity with isolated mitochondria. These activities are qualitatively similar to that reported for the oligomeric mixture of 15-dehydro-PGB1, termed PGBX. |
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