The influence of clinical and anthropometric parameters on the serum levels of the endothelin-1 in pregnant women and their newborns |
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Authors: | Sarunić Alenka Vukelić Cvijanović Olga Dudarić Luka Denona Branko Vukelić Lucian Bobinac Dragica Finderle Aleks |
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Affiliation: | University of Rijeka, Rijeka University Hospital Center, Department of Perinatology, Clinic for Gynecology, Croatia. alenka7@net.hr |
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Abstract: | Pregnancy induced hypertension (PIH) is major contributor to maternal death in developing countries. Endothelin-1 (ET-1) is the most potent vasoconstriction agent known and its serum levels are increased in PIH. Therefore it is important to elucidate maternal and neonatal factors which influence endothelin-1 serum levels. 100 pathological pregnancies and 88 controls were analyzed for blood endothelin-1 and their anthropometric and clinical data were collected. In maternal blood ET-1 levels were strongly predicted by diagnosis, therapy and BMI, while umbilical cord ET-1 levels were strongly predicted by gestational age, therapy and delivery termination. Positive correlation between BMI and ET-1 levels suggest that obese pregnant women have increased risk for cardiovascular diseases. Inverse relationship between Apgar and umbilical ET-1 indicates that ET-1 could be considered as a prognostic marker in cases of neonatal asphyxia. |
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