Synthesis of antitumor 6-alkylidenepenicillanate sulfones and related 3-alkylidene-2-azetidinones |
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| Authors: | Veinberg Grigory Shestakova Irina Vorona Maxim Kanepe Iveta Lukevics Edmunds |
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| Affiliation: | Latvian Institute of Organic Synthesis, 21 Aizkraukles Street, Riga, LV 1006, Latvia. veinberg@osi.lv |
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| Abstract: | 6-alkylidenepenicillanate sulfoxides and sulfones were synthesized on the base of 6-oxopenicillanate esters. The targeted splitting of their thiazolidine ring led to the formation of 3-alkylidene substituted 4-heteryldithio and 4-methylsulfonyl azetidin-2-ones. Some of mono and bicyclic beta-lactams revealed potent cytotoxic properties towards monolayer tumor cells in <10-microM concentrations. |
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