Calcium channels in undifferentiated PC12 rat pheochromocytoma cells |
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| Authors: | D Janigro G Maccaferri J Meldolesi |
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| Affiliation: | Department of Pharmacology, S. Raffaele Scientific Institute, University of Milan, Italy. |
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| Abstract: | Undifferentiated rat pheochromocytoma PC12 cells were voltage clamped using the whole cell technique. After blockade of outward currents, calcium currents were elicited from -40 and -100 mV. A subpopulation of cells displayed only one current component activated at -10 mV and slowly decaying. In other cells this current coexisted with a component activated around -40 mV and decaying with a faster time constant. We conclude that undifferentiated PC12 cells can express two types of calcium channels, L (long-lasting) and N (neuronal)-type channels. |
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