Bioactive sucrose esters from Bidens parviflora |
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Authors: | Wang Naili Yao Xinsheng Ishii Rie Kitanaka Susumu |
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Institution: | Department of Natural Products Chemistry, Shenyang Pharmaceutical University, 103, Wenhua Road Shenhe District Shenyang, Shenyang 110015, China. wangl888@sina.com |
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Abstract: | An investigation on Bidens parviflora led to the isolation of three sucrose esters and a substituted truxillate. Their structures were elucidated as (6-O-(E)-p-coumaroyl)-beta-D-fructofuranosyl-(2-->1)-alpha-D-glucopyranoside, (6-O-(E)-p-coumaroyl)-beta-D-fructofuranosyl-(2-->1)-(6-O-(E)-p-coumaroyl)-alpha-D-glucopyranoside II, 6,6'-sucrose ester of (1alpha,2alpha,3beta,4beta)-3,4-bis(4-hydroxyphenyl)-1,2-cyclobutanedicarboxylic acid, dimethyl ester of (1alpha,2alpha,3alpha,4alpha)-2,4-bis(3,4-dihydroxyphenyl)-1,3-cyclobutanedicarboxylic acid on the basis of spectral and chemical evidence. These compounds were subjected to the following bioassays: the histamine release inhibition of rat mast cells induced by antigen-antibody reaction and the inhibitory activity of PGE(2) production by macrophages. |
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Keywords: | Bidens parviflora Willd Compositae Sucrose ester Truxillic and truxinic acids Histamine release inhibitor PGE2 production inhibitor |
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