Effects of chronic anabolic steroid treatment on tonic and reflex cardiovascular control in male rats |
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| Authors: | Beutel Abram Bergamaschi Cássia Toledo Campos Ruy Ribeiro |
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| Institution: | 1. Cardiology, University Heart Center, University Hospital Zürich, Zürich, Switzerland;2. Institute of Diagnostic and Interventional Radiology, University Hospital Zürich, Zürich, Switzerland;3. Faculty Mechanical and Medical Engineering, Furtwangen University, Villingen-Schwenningen, Germany;4. Cardiovascular Surgery, University Heart Center, University Hospital Zürich, Zürich, Switzerland;1. Neonatal Intensive Care Unit, John Hunter Children''s Hospital, Newcastle, Australia;2. University of Newcastle, Newcastle, Australia;3. Mothers and babies research centre, Hunter Medical Research Institute, Newcastle, Australia;1. Awhina Health Campus, Waitemata District Health Board, Auckland, New Zealand;2. University of Verona, Verona, Italy;3. Karolinska Institute, Sweden;4. Cleveland Clinic Foundation, OH, USA;5. Chinese University of Hong Kong, Hong Kong, China;6. Fondazione IRCCS Policlinico San Matteo, Pavia, Italy;7. Santa Chiara Hospital, University of Pisa, Pisa, Italy;8. St Vincents Hospital, Melbourne, Australia;9. Christchurch School of Medicine, University of Otago, Christchurch, New Zealand;10. Fondazione Salvatore Maugeri, IRCCS, Veruno (Italy);11. Department of Medicine, University Of Auckland, Auckland, New Zealand;12. Unitec Institute of Technology, Auckland, New Zealand |
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| Abstract: | The aim of this study was to analyze the cardiovascular effects of chronic stanozolol administration in male rats. The rats were randomly assigned to one of three groups: (1) control (n=12), (2) chronic treatment with low dose of stanozolol (LD, n=18, 5 mg/kgweek) and; (3) treatment with high dose of stanozolol (HD, n=28, 20 mg/kgweek). Mean arterial pressure (MAP) was higher in both HD (128+/-2.2 mmHg) and LD (126+/-2.5 mmHg) than control (116+/-2 mmHg). The LD group showed an increase in cardiac output (control 121+/-2.5, LD 154+/-5.9 ml/min), whereas in the HD group total peripheral resistance increased (control 1.03+/-0.07, HD 1.26+/-0.07 mmHg/ml/min). Acute sympathetic blockade caused a similar decrease in MAP in all groups. In conscious rats, the baroreflex index for bradycardia (control -3.7+/-0.4, LD -2.0+/-0.1 beat/mmHg) and tachycardia (control -3.6+/-0.3, LD -4.7+/-0.2 beat/mmHg) responses changed only in the LD group. Cardiac hypertrophy was observed in both treated groups (P<0.05). In conclusion, hypertension with differential hemodynamic changes and alterations in the reflex control in heart rate is seen at different stanozolol doses, which may be important variables in the cardiovascular effects of anabolic steroids. |
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