Differential effect of neomycin on DNA dependent -DNA and RNA synthesis in vitro |
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Authors: | D K Dube S Palit |
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Affiliation: | Department of Biochemistry University College of Science Calcutta University 35 Ballygunge Circular Road Calcutta - 700 019, India |
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Abstract: | Neomycin inhibits DNA dependent DNA and RNA synthesis catalyzed by DNA polymerase I and RNA polymerase from . The effect of the antibiotic is more pronounced towards DNA synthesis. The inhibition of DNA synthesis is competitive with template DNA, does not reverse with excess deoxynucleoside triphosphate, Mg2+ or enzyme DNA polymerase I. Neomycin does not reduce the number of potential 3′ -OH end or primer. It seems to shorten the size of the newly formed polynucleotide. |
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