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Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: results of a global collaboration |
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| Authors: | Kantor Rami Katzenstein David A Efron Brad Carvalho Ana Patricia Wynhoven Brian Cane Patricia Clarke John Sirivichayakul Sunee Soares Marcelo A Snoeck Joke Pillay Candice Rudich Hagit Rodrigues Rosangela Holguin Africa Ariyoshi Koya Bouzas Maria Belen Cahn Pedro Sugiura Wataru Soriano Vincent Brigido Luis F Grossman Zehava Morris Lynn Vandamme Anne-Mieke Tanuri Amilcar Phanuphak Praphan Weber Jonathan N Pillay Deenan Harrigan P Richard Camacho Ricardo Schapiro Jonathan M Shafer Robert W |
| Affiliation: | Division of Infectious Disease and Center for AIDS Research, Stanford University, Stanford, California, USA. rkantor@brown.edu |
| Abstract: | BackgroundThe genetic differences among HIV-1 subtypes may be critical to clinical management and drug resistance surveillance as antiretroviral treatment is expanded to regions of the world where diverse non-subtype-B viruses predominate.ConclusionGlobal surveillance and genotypic assessment of drug resistance should focus primarily on the known subtype B drug-resistance mutations. |
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