Sister chromatid exchanges in leukocytes of patients with cancer of cervix uteri |
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| Authors: | A B Mitra V V V S Murty U K Luthra |
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| Institution: | (1) Cytology Research Centre (Indian Council of Medical Research), Maulana Azad Medical College Campus, 1100 02 New Delhi, India |
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| Abstract: | Summary The frequency of sister chromatid exchange (SCE) was investigated in 13 women with cervical cancer together with 11 control women. The SCE frequencies were found to be 10.05±2.35 and 6.95±1.53 in cancer cases and controls, respectively. The SCE values of cancer cases deviate significantly from that of controls. The SCE in chromosome groups E, F, and G was found to be more in comparison to controls (P<0.001). This preliminary study indicates the possibility of using SCE as a preclinical marker. |
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