A lysosomal factor that interconverts multiple forms of rat liver tyrosine aminotransferase. |
| |
Authors: | G J Smith P H Pearce I T Oliver |
| |
Abstract: | A particulate factor of rat liver is described which interconverts three forms of rat liver cytosolic tyrosine aminotransferase with no alteration of enzyme activity. The factor appears to be a heat- and pH-sensitive lysosomal protein. The interconversion process is stimulated by 2.5 mM MgCl2 and 2.5 mM ATP. Asparate aminotransferase multiple forms are also susceptible to interconversion by the lysosomal factor. The properties of the factor explain several anomalous effects of manipulation on the tyrosine aminotransferase forms which have been reported in the literature and implicate the form interconversion in the degradation of tyrosine aminotransferase. |
| |
Keywords: | To whom reprint requests should be sent |
本文献已被 ScienceDirect 等数据库收录! |