首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Role of caspases in TNF-mediated regulation of cPLA(2)
Authors:Krönke Martin  Adam-Klages Sabine
Institution:Institute for Medical Microbiology, Immunology, and Hygiene, Medical Center, University of Cologne, Goldenfelsstr. 19-21, 50935, Cologne, Germany. martin.kroenke@medizin.uni-koeln.de
Abstract:A major part of the proinflammatory activity of tumor necrosis factor (TNF) is brought about by cytosolic phospholipase A(2) (cPLA(2)) that generates arachidonic acid, the precursor for the production of leukotrienes and prostaglandins. The activation of cPLA(2) and induction of proinflammatory lipid mediators is in striking contrast to the teleologic meaning of apoptosis, which is to avoid an inflammatory reaction. In this review we highlight the evidence for a caspase-mediated cleavage and inactivation of cPLA(2), which seems to be an important mechanism by which TNF downregulates cPLA(2) activity in cells undergoing apoptosis.
Keywords:Cytosolic phospholipase A2  Tumor necrosis factor  Death domain  Caspase
本文献已被 ScienceDirect PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号