Synthesis and cytotoxic activity of trisubstituted-1,3,5-triazines |
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Authors: | Arya Kapil Dandia Anshu |
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Institution: | Indian Oil Corporation Limited, R&D Center, Faridabad, Haryana 121007, India. aryakapil2001@yahoo.com |
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Abstract: | 1,3,5-Triazine derivatives were screened for phototoxicity as well as the cytotoxic activities against leukemia and adenocarcinoma derived cell lines in comparison to the normal human keratinocytes. A simple and environmentally friendly procedure has been developed for the synthesis of 1,3,5-triazine derivatives under microwave irradiation in the presence of a HY zeolite. The catalyst can be recovered and reused. Thus, the procedure provides a simple and green synthetic methodology under environmentally friendly conditions. Structure-activity relationships between the chemical structures and antimycobacterial and photosynthesis-inhibiting activity of the evaluated compounds are also discussed. |
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