A unifying model for reconstructing radiosensitivity from micronucleus formation,apoptosis and abnormal morphology |
| |
| Authors: | Akudugu J M Abend M Böhm L |
| |
| Affiliation: | Department of Radiation Oncology, Faculty of Health Sciences and Tygerberg HospitalUniversity of Stellenbosch, P.O. Box 19063, 7505, Tygerberg, South Africa. jakudugu@uhnres.utoronto.ca |
| |
| Abstract: | At present micronucleus data cannot predict cellular radiosensitivity. The inclusion of data from apoptosis and abnormal morphology has not entirely resolved this problem. Here, we assess the probability of cell death arising from events other than micronucleation, apoptosis and abnormal morphology (i.e. lesions not detected by these damage assays) P(oe), for its ability to reflect intrinsic cellular radiosensitivity. Analysis of data from 17 cell lines used in two separate studies, spanning a wide range of radiosensitivity (0.09
|
| |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
