Impaired regulation of corticosterone levels during fasting in aging rats. |
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| Authors: | G W Britton S Rotenberg R C Adelman |
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| Affiliation: | Fels Research Institute and Department of Biochemistry Temple University School of Medicine Philadelphia, Pennsylvania 19140, USA |
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| Abstract: | The concentration of corticosterone in aortal blood of 3-day fasted rats decreases approximately 75% between 2- and 24-months of age. The reduced level of hormone in aging rats is not attributable to an enhanced rate of corticosterone utilization from the blood or to a diminished steroidogenic capacity of the adrenal cortex, but apparently reflects a deficiency in extraadrenal regulatory mechanisms. |
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| Keywords: | To whom correspondence should be sent. |
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