Longitudinal analysis of VP7 gene of group A human rotavirus G2P[4] strains circulating in the pre‐vaccine era in Sapporo,Japan from 1991 to 2011 |
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| Authors: | Masatoshi Tatsumi Yoshinobu Nagaoka Takeshi Tsugawa Yuko Yoto Tsukasa Hori Hiroyuki Tsutsumi |
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| Affiliation: | 1. Department of Pediatrics, Sapporo Medical University School of Medicine, , Sapporo, 060‐8543 Japan;2. Otaru Kyokai Hospital, Otaru City, , Japan |
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| Abstract: | Sequence analysis of the VP7 gene in 23 group A human rotavirus G2P[4] strains obtained during 1991–2011, that is, the pre‐vaccine era, in Sapporo, Japan showed considerable genetic diversity, mainly in variable regions. Recent G2P[4] epidemic strains were located in sublineage IVa with a distinctive substitution of D96N. This study provides background data on the genetic variability of G2P[4] rotavirus‐VP7 gene prior to the widespread use of rotavirus vaccines in Japan. |
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| Keywords: | acute gastroenteritis G2P[4] human rotavirus VP7 |
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