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Antimicrobial susceptibility profile of Acinetobacter species isolated from blood cultures in two Japanese university hospitals |
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| Authors: | Kozue Kishii Ken Kikuchi Atsushi Yoshida Katsuko Okuzumi Yushi Uetera Hiroshi Yasuhara Kyoji Moriya |
| Institution: | 1. Department of Quality Assessment and Control of Medical Device Sterilization, Graduate School of Medicine, University of Tokyo, , Hongo, Bunkyo‐ku, Tokyo, 113‐8655 Japan;2. Department of Infection Control Science, Faculty of Medicine, Juntendo University, , Hongo, Bunkyo‐ku, Tokyo, 113‐8421;3. Division of Infection Control, Dokkyo Medical University Hospital, , Shimotsuga‐gun, Tochigi, 321‐0293;4. Surgical Center;5. Department of Infection Control and Prevention, University of Tokyo Hospital, , Hongo, Bunkyo‐ku, Tokyo, 113‐8655 Japan |
| Abstract: | Carbapenem‐resistant Acinetobacter baumannii has rapidly spread worldwide. This study investigated antibiotic susceptibility and genotypic resistance of 123 consecutive blood culture isolates of Acinetobacter species collected between 2003 and 2011 in two Japanese hospitals. The isolates were assigned to 13 species. Carbapenem resistance was detected in four isolates. Only one A. baumannii isolate had blaOXA‐23 together with ISAba1; the remaining three isolates had IMP‐1 metallo‐β‐lactamase. Quinolone resistance was detected in five isolates that had point mutations in the quinolone resistance‐determining region. The predominance of various non‐A. baumannii species and low prevalence of carbapenem resistance among blood culture isolates of Acinetobacter species in two Japanese hospitals were confirmed. |
| Keywords: | blaOXA23 IMP‐1 non‐Acinetobacter baumannii complex quinolone resistance‐determining region |