MHC class I molecules are incorporated into human herpesvirus‐6 viral particles and released into the extracellular environment |
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| Authors: | Megumi Ota Satoshi Serada Tetsuji Naka Yasuko Mori |
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| Institution: | 1. Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, , Chuo‐ku, Kobe, 650‐0017 Japan;2. Laboratory of Immune Signal, Division of Biomedical Research, National Institute of Biomedical Innovation, , Ibaraki, Osaka, 567‐0085 Japan |
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| Abstract: | Human herpesvirus‐6 (HHV‐6), which belongs to the betaherpesvirus subfamily, mainly replicates in T lymphocytes. Here, we show that MHC class I molecules are incorporated into HHV‐6 viral particles and released into the extracellular environment. In addition, HHV‐6A/B‐infected T cells showed reduced surface and intracellular expression of MHC class I molecules. The cellular machinery responsible for molecular transport appears to be modified upon HHV‐6 infection, causing MHC class I molecules to be transported to virion assembly sites. |
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| Keywords: | human herpesvirus‐6A/B MHC class I viral particles |
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