MALDI imaging mass spectrometry: molecular snapshots of biochemical systems |
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Authors: | Cornett Dale S Reyzer Michelle L Chaurand Pierre Caprioli Richard M |
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Affiliation: | Mass Spectrometry Research Center, 465 21st Avenue, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA. |
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Abstract: | Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is emerging as a powerful tool for investigating the distribution of molecules within biological systems through the direct analysis of thin tissue sections. Unique among imaging methods, MALDI-IMS can determine the distribution of hundreds of unknown compounds in a single measurement. We discuss the current state of the art of MALDI-IMS along with some recent applications and technological developments that illustrate not only its current capabilities but also the future potential of the technique to provide a better understanding of the underlying molecular mechanisms of biological processes. |
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