The human cytomegalovirus US8 glycoprotein binds to major histocompatibility complex class I products |
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| Authors: | Tirabassi Rebecca S Ploegh Hidde L |
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| Institution: | Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA. |
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| Abstract: | Human cytomegalovirus US8 is a type I membrane protein that partially colocalizes with cellular endosomal and lysosomal proteins. Although US8 does not have discernible effects on the processing and cell surface distribution of major histocompatibility complex (MHC) class I products, we have demonstrated that US8 binds to MHC class I heavy chains in the endoplasmic reticulum. |
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