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Targeting of colloidal particles to the bone marrow |
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| Authors: | L Illum S S Davis |
| Affiliation: | 1. Musculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Hong Kong, China;2. Translational Medicine R&D Center, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, PR China |
| Abstract: | Since intravenously administered colloidal particles are normally removed efficiently by the reticuloendothelial cells of the liver and spleen only a small fraction of these particles will reach the bone marrow. By coating model microspheres with a block co-polymer (poloxamer 407) it has been possible effectively to hinder the liver/spleen uptake and obtain a deposition of the microspheres primarily in the bone marrow. Such a carrier system will have application in radiodiagnosis and for treatment of various diseases in the bone marrow. |
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