Trypanosoma congolense: surface glycoproteins of two early bloodstream variants. I. Production of a relapsing infection in rodents |
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| Authors: | N L Rosen M Onodera P J Hotez M S Bogucki B Elce C Patton W H Konigsberg G A Cross F F Richards |
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| Institution: | 1. Department of Molecular Biochemistry and Biophysics, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, U.S.A.;2. Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, U.S.A.;4. Departments of Epidemiology and Public Health, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, U.S.A.;3. Department of Biology, Brunel University, Uxbridge, England, U.K. |
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| Abstract: | A strain of Trypanosoma congolense has been cloned, passaged through the tsetse fly, and subsequently recloned. Relapsing infections have been induced in two rats by syringe passage of the cloned trypanosomes. The variant-specific glycoprotein of the initial cloned variant (VSG-1) and those from the two different variants produced in the two relapsing infections (VSG-2 and VSG-3) may be distinguished from each other by their isoelectric-focusing patterns. In this experimental system, cloned T. congolense, like Trypanosoma brucei, undergoes antigenic variation; the conversion of the VSG-1 into the VSG-2 isoelectric-focusing spectrotype was followed. These VSGs may be the products of sequentially expressed genes. |
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| Keywords: | Hemoflagellate Protozoa parasitic Antigenic variation Clone Isoelectric focusing Rat Mouse |
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