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Circulating nitric oxide metabolites and the risk of cardiometabolic outcomes: a prospective population-based study |
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| Authors: | Parvin Mirmiran Zahra Bahadoran Zhaleh Tahmasebinejad Fereidoun Azizi |
| Institution: | 1. Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran;2. Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran |
| Abstract: | Aim: This study was conducted to investigate whether serum NO metabolites (NOx) could predict the occurrence of type 2 diabetes (T2DM), hypertension (HTN) and metabolic syndrome (MetS). Methods: We measured serum NOx concentrations in the Tehran Lipid and Glucose Study participants (aged ≥19?years) and followed them for a median of 7.7?years for the incidence of outcomes. To determine the appropriate cut-off points of serum NOx for predicting clinical events, a random sampling method (50:50 ratio) was used for the population and for analysis, receiver operator characteristic curve was used. Multivariable Cox proportional hazard models were used to estimate the hazard ratios (HRs) with 95% confidence intervals (95% CIs) of T2DM, HTN and MetS in response to serum NOx values. Results: The optimal cut-off points of serum NOx levels for predicting T2DM, HTN and MetS were 26.5, 25.5 and 25.5?µmol/L, respectively. Participants with serum NOx levels ≥25.5?µmol/L had increased risk of MetS (HR?=?1.31, 95% CI?=?1.01–1.72). No evidence was found for any association of serum NOx with incidence of T2DM and HTN (HR?=?1.03, 95% CI?=?0.83–1.77 and HR?=?1.09, 95% CI?=?0.88–1.35). Conclusion: In this prospective population-based investigation, a higher circulating NOx was associated with development of MetS. |
| Keywords: | Nitric oxide metabolites type 2 diabetes hypertension metabolic syndrome cut-off points |