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Association between high-sensitivity cardiac troponin T and future cardiovascular incidence in a general Japanese population: results from the Tohoku medical megabank project |
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| Authors: | Yuji Takahashi Hideki Ohmomo Fumitaka Tanaka Takuya Osaki Kozo Tanno |
| Affiliation: | 1. Division of Cardiology, Department of Internal Medicine, Iwate Medical University, Morioka, Japan;2. Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University, Morioka, Japan;3. Division of Cardioangiology, Nephrology and Endocrinology, Department of Internal Medicine, Iwate Medical University, Morioka, Japan;4. Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University, Morioka, Japan;5. Department of Hygiene and Preventive Medicine, Iwate Medical University, Morioka, Japan |
| Abstract: | Purpose: Elevation of high-sensitivity cardiac troponin T (hs-cTnT) is associated with an increased risk of cardiovascular disease (CVD). This study determined whether hs-cTnT was detectable with N-terminal pro-b-type natriuretic peptide (NT-proBNP) and related to CV risk factors in a general Japanese population. Materials and methods: The Tohoku Medical Megabank Organization pooled individual participant data for a population-based cohort study in the Iwate prefecture (n?=?30,193, age = 60.2?±?11.5?year). Results: Hs-cTnT levels were higher in participants with hypertension, diabetes mellitus than in participants without these conditions (all ps < 0.001). Logistic regression analysis demonstrated that NT-proBNP was strongly associated with elevation of hs-cTnT (OR = 3.35, 95% CI = 2.90–3.89, p?p? Conclusions: Hs-cTnT levels are associated with elevation of NT-proBNP and high Suita score, which suggests that elevated hs-cTnT is related to subclinical myocardial damage and indicates CV risk. |
| Keywords: | Atherosclerosis cardiovascular disease cohort study N-terminal pro-b-type natriuretic peptide |