Determination of the inhibitory effects of N-methylpyrrole derivatives on glutathione reductase enzyme |
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| Authors: | Esma Kocaoğlu Hüseyin Çavdar Murat Şentürk Deniz Ekinci |
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| Affiliation: | 1. Kamil Ozdag Science Faculty, Karamanoglu Mehmet Bey University, Karaman, Turkey;2. Education Faculty, Dumlup?nar University, Kütahya, Turkey;3. Pharmacy Faculty, Agri Ibrahim Cecen University, Agri, Turkey;4. Ondokuz Mayis University, Faculty of Agriculture, Department of Agricultural Biotechnology, Samsun, Turkey |
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| Abstract: | Glutathione reductase (GR) is a crucial antioxidant enzyme which is responsible for the maintenance of antioxidant GSH molecule. Antimalarial effects of some chemical molecules are attributed to their inhibition of GR, thus inhibitors of this enzyme are expected to be promising candidates for the treatment of malaria. In this work, GR inhibitory properties of N-Methylpyrrole derivatives are reported. It was found that all compounds have better inhibitory activity than the strong GR inhibitor N,N-bis(2-chloroethyl)-N-nitrosourea, especially three molecules, 8?m, 8 n, and 8 q, were determined to be the most powerful among them. Findings of our study indicates that these Schiff base derivatives are strong GR inhibitors which can be used as leads for designation of novel antimalarial candidates. |
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| Keywords: | N-methylpyrrole coupling glutathione reductase antimalaria antioxidant |
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