|
|||||
|
|
Stereoselective binding of benzodiazepines and related compounds on calmodulin-sepharose |
|
| Authors: | Ilona Fitos,Jü alia Visy,Julianna Kardos,Mikl as Simonyi |
| Affiliation: | Ilona Fitos,Jüalia Visy,Julianna Kardos,Miklóas Simonyi |
| Abstract: | A method has been presented to evaluate the Ca2+-dependent binding affinity of ligands to calmodulin (CaM) from their chromatographic retentions obtained on a CaM-Sepharose column. Enantiomers of benzodiazepines and related compounds could be separated. Among chiral calcium antagonists, verapamil showed stereoselectivity of binding. © 1995 Wiley-Liss, Inc. |
| Keywords: | chiral interaction affinity chromatography benzodiazepines phenothiazines calcium antagonists |