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Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3
Affiliation:1. Institute of Virology, Helmholtz Zentrum München, Neuherberg, Germany;2. Department of Genome-Oriented Bioinformatics, Technical University Munich, Munich, Germany;3. Developmental Biology and Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA;4. Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany;5. Assay Development and Screening Platform, Helmholtz Zentrum München, Neuherberg, Germany;6. Institute of Human Genetics, University of Saarland, Homburg, Germany
Abstract:
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  • Keywords:HERV  endogenous retrovirus  retrotransposon  CRISPR  influencing cortical neuronal development  Neurotrophic Tyrosine Receptor Kinase 3  NTRK3  forebrain orgnoid
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