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Prior infection with SARS-CoV-2 boosts and broadens Ad26.COV2.S immunogenicity in a variant-dependent manner
Institution:1. Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa;2. Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa;3. National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa;4. MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa;5. Department of Medicine, University of Cape Town and Groote Schuur Hospital, South Africa;6. Division of Chemical and Systems Biology, Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town, South Africa;7. National Infection Service, Public Health England, Porton Down, UK;8. Division of Infection and Immunity, University College London, London, UK;9. Institute of Cardiovascular Sciences, University College London, London, UK;10. Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, UK;11. Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA;12. Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, CA, USA;13. NHLS Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa;14. Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Cape Town, South Africa;15. South African Medical Research Council, Cape Town, South Africa;16. Centre for the AIDS Programme of Research in South Africa, Durban, South Africa;17. Discipline of Public Health Medicine, University of KwaZulu-Natal, Durban, South Africa;18. Desmond Tutu HIV Centre, Cape Town, South Africa;19. Hatter Institute for Cardiovascular Research in Africa, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Abstract:
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  • Keywords:neutralization  Fc effector function  vaccines  SARS-CoV-2  Ad26CoV2  S  variants of concern  hybrid immunity
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