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An AAV-based,room-temperature-stable,single-dose COVID-19 vaccine provides durable immunogenicity and protection in non-human primates
Affiliation:1. Grousbeck Gene Therapy Center, Schepens Eye Research Institute, Mass Eye and Ear, Boston, MA, USA;2. Ocular Genomics Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA;3. The Broad Institute of Harvard and MIT, Cambridge, MA, USA;4. Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA;5. Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Université Paris-Saclay, Inserm, CEA, Fontenay-aux-Roses, France;6. Gene Therapy Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;7. Novartis Gene Therapies, San Diego, CA, USA;8. Novartis Gene Therapies, NC, USA;9. Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;10. Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;11. Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA;12. Department of Medicine, Harvard Medical School, Boston, MA, USA;13. Department of Microbiology and National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston, MA 02118, USA;14. Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA;15. Molecular Genetics of RNA Viruses, Department of Virology, Institut Pasteur, CNRS UMR 3569, Université de Paris, Paris, France;16. National Reference Center for Respiratory Viruses, Institut Pasteur, Paris, France;17. Translational Innovation Fund, Mass General Brigham Innovation, Cambridge, MA, USA;18. Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA;19. Department of Microbiology, Harvard Medical School, Boston, MA, USA;20. Albamunity, Boston, MA, USA;21. Novartis Gene Therapies, Libertyville, IL, USA;22. Center for Computational & Integrative Biology, Department of Medicine, and Translational Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Abstract:
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  • Keywords:adeno-associated virus  AAV  SARS-CoV-2  COVID-19  vaccine  immunization  single dose  room-temperature stable  viral challenge  durability
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