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A bacterial bile acid metabolite modulates Treg activity through the nuclear hormone receptor NR4A1
Affiliation:1. Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA;2. Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA;3. Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA;4. Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA;5. Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA;6. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;7. Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK;8. Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA 02115, USA
Abstract:
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  • Keywords:human microbiome  bile acids  T cells  inflammatory bowel disease
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