Serological Cross-Reactivity between Merkel Cell Polyomavirus and Two Closely Related Chimpanzee Polyomaviruses |
| |
| Authors: | Jér?me T J Nicol Etienne Liais Romain Potier Elisa Mazzoni Mauro Tognon Pierre Coursaget Antoine Touzé |
| |
| Institution: | 1. Université François Rabelais, Virologie Immunologie Moléculaires, Tours, France.; 2. INRA UMR 1282, Infectiologie et Santé Publique, Tours, France.; 3. Association Beauval Nature pour la Conservation et la Recherche, Saint Aignan sur Cher, France.; 4. Department of Morphology, Surgery and Experimental Medicine, School of Medicine, University of Ferrara, Ferrara, Italy.; Penn State University School of Medicine, United States of America, |
| |
| Abstract: | Phylogenetic analyses based on the major capsid protein sequence indicate that Merkel cell polyomavirus (MCPyV) and chimpanzee polyomaviruses (PtvPyV1, PtvPyV2), and similarly Trichodysplasia spinulosa-associated polyomavirus (TSPyV) and the orangutan polyomavirus (OraPyV1) are closely related. The existence of cross-reactivity between these polyomaviruses was therefore investigated. The findings indicated serological identity between the two chimpanzee polyomaviruses investigated and a high level of cross-reactivity with Merkel cell polyomavirus. In contrast, cross-reactivity was not observed between TSPyV and OraPyV1. Furthermore, specific antibodies to chimpanzee polyomaviruses were detected in chimpanzee sera by pre-incubation of sera with the different antigens, but not in human sera. |
| |
| Keywords: | |
|
|
