Clinical value of (18)F-FDG PET/CT in postoperative monitoring for patients with colorectal carcinoma |
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| Authors: | Han Anqin Xue Jie Zhu Dongyuan Zheng Jinsong Yue Jinbo Yu Jinming |
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| Institution: | aDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, China;bKey Laboratory of Radiation Oncology of Shandong Province, Shandong Cancer Hospital and Institute, Jinan, China;cDepartment of Oncology, Hospital Affiliated to Shandong Academy of Medical Science, Jinan, China;dDepartment of Nuclear Medicine, Shandong Cancer Hospital and Institute, Jinan, China |
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| Abstract: | Objective: To evaluate the clinical value of 18F-FDG PET/CT in postoperative monitoring for patients with colorectal carcinoma. Methods: 66 postoperative patients with colorectal carcinoma underwent whole-body FDG PET/CT. The final histopathological and formal clinical follow-up findings were used as gold standard to determine the sensitivity and specificity of FDG PET/CT and enhanced CT of the same periods. Results: The sensitivity and specificity of FDG PET/CT in detecting recurrence are 96.30%, 94.87% (while enhanced CT are 70.37% and 87.18% respectively). The sensitivity and specificity in detecting metastasis are 95.35%, 82.61% (enhanced CT are 61.90%, 75.00%). SUVmax was significantly higher in malignant lesions range 4.16–22.00, mean ± standard deviation (x ± s) 8.06 ± 4.30] than in benign ones (range1.18–6.25, x ± s 2.82 ± 1.02). Conclusion: At present, whole-body 18F-FDG PET/CT is an advanced diagnostic imaging technique in detecting loco-regional recurrence and metastasis in postoperative patients with colorectal carcinoma for its higher sensitivity and specificity. |
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| Keywords: | Colorectal carcinoma Postoperative 18F-fluoro-2-deoxyglucose (FDG) Standardized uptake value (SUV) Recurrence Metastasis Detecting Positron emission tomography (PET) |
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