CYP17 gene polymorphism and prostate cancer susceptibility in a Tunisian population |
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| Authors: | Souiden Yousra Mahdouani Manel Chaieb Kamel Elkamel Rafik Mahdouani Kacem |
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| Institution: | aLaboratory of Molecular Biology, Hospital of Ibn Eljazzar of Kairouan, Avenue Ibn Eljazzar, Kairouan 3140, Tunisia;bLaboratory of Analysis, Treatment and Valorization of the Pollutants of the Environment and Products, Faculty of Pharmacy, Rue Ibn Sina, Monastir 5000, Tunisia;cDepartment of Urology, Hospital of Ibn Eljazzar of Kairouan, Rue Fess, Kairouan 3140, Tunisia |
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| Abstract: | Prostate cancer (PCa) formation has been reported to be associated with androgen. Two key steps in the sex steroid synthesis are mediated by the enzyme cytochrome P450c 17α which is encoded in the CYP17 gene. The A2 allele of the CYP17 gene has been thought to be associated with increased functional activity of this steroidogenic enzyme. Consequently, the A2 allele has been examined as a biomarker of individual susceptibility to hormone-related diseases among men. We prospectively assessed the association between the A2 allele of CYP17 and PCa risk among 125 cases and 125 controls in a case–control study. Our aim was to investigate whether a polymorphism of CYP17 gene could be used as a genetic marker for associating PCa. The result revealed a significant association between the CYP17 polymorphic genotypes and PCa. Therefore, CYP17 gene polymorphism is likely contributed to the pathogenesis of PCa but not to disease severity. |
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| Keywords: | Prostate cancer CYP17 Polymorphism Tunisian population |
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