Autoradiographic localization of 3H-GABA uptake in the thyroid gland of the rat

Summary The uptake of -aminobutyric acid (GABA) in the thyroid gland of the rat was studied autoradiographically following in vitro incubation.High-affinity GABA uptake was localized in follicle cells, whereas C cells (parafollicular cells) in general did not accumulate GABA by high-affinity transport. The follicle cells were also the main sites of low-affinity GABA uptake. Additionally, some nerve fibres were found to accumulate GABA.The predominant localization of GABA uptake in follicle cells is discussed in view of a presumed role of GABA in thyroid function.