Change of nuclear ribonuclease H activity following deoxyribonucleic acid synthesis in liver of protein-deficient rat |
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| Authors: | Y Sawai K Wada K Tsukada |
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| Affiliation: | Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, Kandasurugadai, Chiyoda-ku, Tokyo 101, Japan |
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| Abstract: | The activities of RNA polymerase I and Mg2+ - dependent ribonuclease H (RNase H) become doubled in the liver nuclei of rats that are fed for several days a diet that lacks amino acids or protein. Both Mn2+- and Mg2+- dependent RNases H activities increased two- to three-fold in the liver nuclei of rats in which hepatic DNA replication has been induced by a dietal manipulation. |
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