Desorption electrospray ionization mass spectrometry for lipid characterization and biological tissue imaging |
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| Authors: | Eberlin Livia S Ferreira Christina R Dill Allison L Ifa Demian R Cooks R Graham |
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| Affiliation: | Department of Chemistry, Purdue University, West Lafayette, IN, USA. |
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| Abstract: | Desorption electrospray ionization mass spectrometry (DESI-MS) imaging of biological samples allows untargeted analysis and structural characterization of lipids ionized from the near-surface region of a sample under ambient conditions. DESI is a powerful and sensitive MS ionization method for 2D and 3D imaging of lipids from direct and unmodified complex biological samples. This review describes the strengths and limitations of DESI-MS for lipid characterization and imaging together with the technical workflow and a survey of applications. Included are discussions of lipid mapping and biomarker discovery as well as a perspective on the future of DESI imaging. |
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