人t-PA溶栓突变体的研究进展

人t-PA在机体循环中的纤溶系统中起重要作用，是一种内源性溶血栓因子,t-PA蛋白分子可直接用于溶栓治疗，但天然的t-PA分子在体内半衰期短，极最被清除，因而限制其广泛应用，根据它的结构特点而改造的一系列t-PA变体分子将成为新一代溶栓药物，在溶栓治疗中广泛应用。

The mutants in tissue plasminogen activators for thrombolytic agents

As a internal thrombolytic agent,t-PA play a key role in plasma fibrinolytic system of organism.t-PA is a mosaic protein containing several distinct structural domains,and can be used directly in thrombolytic treatment.But in plasma the half-life of native t-PA molecules was short,and would be cleared fastly.It is difficult to use widely in clinic.According to the structural characteristics of t-PA,several types of prolonged hife-life mutant tissue plasminogen activators(mt-PA)have been developed.These mt-PA were used widely in clinical therapy of thrombolytic.